Vitamin B12 has incredibly reduced toxicity and even taking it in massive dosages shows up not to be unsafe to healthy individuals.
Hematologic: Peripheral vascular thrombosis has actually been proclaimmed. Treatment of supplement B12 deficiency can unmask polycythemia vera, which is characterized by an increase in blood volume as well as the amount of red blood cells.
The correction of megaloblastic anemia with supplement B12 can result in catastrophic hypokalemia and gout in prone individuals, and it can obscure folate deficiency in megaloblastic anemia. Caution is warranted.
Leber’s disease: Vitamin B12 in the form of cyanocobalamin is contraindicated in early Leber’s disease, which is hereditary optic nerve atrophy.
Cyanocobalamin can easily generate extreme and swift optic atrophy, but additional forms of supplement B12 are obtainable. However, the sources of this statement are not clear, while an opposing view ends. The medical photo of optic neuropathy associated by having supplement B12 deficiency shows similarity to that of Leber’s disease optic neuropathy. Both involve the nerve fibers of the papillomacular package.
The present situation reports recommend that optic neuropathy in patients bringing a primary LHON mtDNA mutation may be precipitated by supplement B12 deficiency. Therefore, known companies should take care to have an adequate nutritional consumption of supplement B12 as well as malabsorption syndromes like those taking place in familial pernicious anemia or after gastric surgical treatment must be excluded.