Supplement B12 is utilized to treat vitamin B12 deficiency, cyanide poisoning, as well as hereditary deficiency of transcobalamin II. It is even given as element of the schilling test to find pernicious anemia.
For cyanide poisoning, a large amount could be provided intravenously, and often in combination by having salt thiosulfate. The mechanism of action is straightforward: the hydroxycobalamin hydroxide ligand is displaced by the toxic cyanide ion, and the resulting undamaging B12 complex is excreted in urine. In the United States, the Food and Drug Administration approved (in 2006) the use of hydroxocobalamin for acute treatment of cyanide poisoning.
High supplement B12 degree in senior individuals may guard brain atrophy or shrinkage, associated in having Alzheimer’s disease and impaired cognitive function.
High-dose administration of Supplement B12 has actually been furthermore legitimized to stimulate the activity of the body’s TH1 suppressor T-Cells, which then down-regulates the over-production of the allergen antibody IgE in allergic individuals.